NEW SYNTHESIS OF 2-BETA-HYDROXY-19-OXOANDROST-4-ENE-3,17-DIONE AND ITS 2-BETA-O-18 ANALOG

Authors
DHARMARATNE HRW SHACKLETON C ROITMAN E CASPI E
Citation
Hrw. Dharmaratne et al., NEW SYNTHESIS OF 2-BETA-HYDROXY-19-OXOANDROST-4-ENE-3,17-DIONE AND ITS 2-BETA-O-18 ANALOG, Journal of steroid biochemistry and molecular biology, 45(6), 1993, pp. 571-580
Citations number
8
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Journal of steroid biochemistry and molecular biology → ACNP
ISSN journal
09600760
Volume
45
Issue
6
Year of publication
1993
Pages
571 - 580
Database
ISI
SICI code
0960-0760(1993)45:6<571:NSO2AI>2.0.ZU;2-6
Abstract
Treatment of 19-[oxygenated]-androst-4-ene-3,17-dione with Mn(AcO)3 an d ClCH2COOH in benzene gave epimeric mixtures of the corresponding 2xi -chloroacetates and 2xi-acetates. The products were processed to give the title compound. For the synthesis of the 2-O-18 analog, (ClCH2COOH )-O-18 was used, which was prepared from ClCH2COCl.