A HIGHLY EFFICIENT ROUTE TO TAXOTERE BY THE BETA-LACTAM SYNTHON METHOD

Authors
OJIMA I SUN CM ZUCCO M PARK YH DUCLOS O KUDUK S
Citation
I. Ojima et al., A HIGHLY EFFICIENT ROUTE TO TAXOTERE BY THE BETA-LACTAM SYNTHON METHOD, Tetrahedron letters, 34(26), 1993, pp. 4149-4152
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
26
Year of publication
1993
Pages
4149 - 4152
Database
ISI
SICI code
0040-4039(1993)34:26<4149:AHERTT>2.0.ZU;2-E
Abstract
Taxotere, a highly promising anticancer drug, is synthesized through a n efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enant iomerically pure (3R,4S)-1-(t)BOC-3-EEO-4-phenylazetidin-2-one which i s obtained via chiral ester enolate - imine cyclocondensation.