A CONVENIENT METHOD FOR SYNTHESIS OF FMOC-AMINO ACID P-NITROANILIDES BASED ON ISOBUTYL CHLOROFORMATE AS A CONDENSATION AGENT

Authors
NEDEV H NAHARISOA H HAERTLE T
Citation
H. Nedev et al., A CONVENIENT METHOD FOR SYNTHESIS OF FMOC-AMINO ACID P-NITROANILIDES BASED ON ISOBUTYL CHLOROFORMATE AS A CONDENSATION AGENT, Tetrahedron letters, 34(26), 1993, pp. 4201-4204
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
26
Year of publication
1993
Pages
4201 - 4204
Database
ISI
SICI code
0040-4039(1993)34:26<4201:ACMFSO>2.0.ZU;2-I
Abstract
Mixed anhydride method with condensation agent isobutyl chloroformate is described for obtaining a series of p-nitroanilides of FMOC-Pro-, F MOC-Ala-, FMOC-Leu-, FMOC-Ile, FMOC-Trp-, FMOC-Asp(OtBu)-, FMOC-Gln(Tr t)-, FMOC-Hyp- and FMOC-Hyp(OtBu)- in good yields and in an optical pu re form. The use of other activating agents for obtaining p-nitroanili des is discussed.