SEQUENTIAL TC99M MERCAPTOACETYL-TRIGLYCINE (MAG3) RENOGRAPHY AS AN EVALUATOR OF EARLY RENAL-TRANSPLANT FUNCTION

A prospective study was carried out to evaluate the role of sequential Tc-99m MAG3 renography in assessing transplant function in the early post-operative period. Twenty patients were included in the study. Stu dies were performed on all patients at intervals of 48-72 hours until discharge. There were 11 clinically diagnosed episodes of rejection, 9 of which were correctly diagnosed using MAG3 renography. Six episodes of rejection were diagnosed prior to the onset of clinical symptom Tw o patients with graft infarction were correctly diagnosed. Six patient s had evidence of transient renographic abnormalities in the immediate post-operative phase which were not associated with clinical symptoms , of these resolved spontaneously on subsequent examinations and were presumed to be related to resolving acute tubular necrosis (ATN). The perfusion index was of no discriminatory value in this study. Sequenti al Tc-99m MAG3 renography is highly sensitive but entirely nonspecific in the evaluation of pathology in the transplant kidney. Rejection in an uncomplicated transplant can be readily detected in many cases wel l in advance of clinical manifestations. This study demonstrates that Tc-99m MAG3 renography is certainly equal to Tc-99m DTPA renography or Iodine 131 renography in assessing early transplant function. However , Tc-99m MAG3 exposes the patient to considerably less radiation and t he images are of superior quality.