PROXIMAL GASTRIC-VAGOTOMY BY MINIMALLY INVASIVE METHODS IN AN ACUTE RAT MODEL

In this prospective study, minimally invasive methods of proximal gast ric vagotomy (PGV) were investigated in male Sprague-Dawley rats. Comp leteness of vagotomy by traditional operative therapy, by laser denerv ation of the gastric serosa, and by subserosal or transmucosal injecti ons of chemoneurolytic agents was evaluated with postoperative Congo r ed testing, ulcerogenic stimulation of the gastric mucosa, and histoch emical labeling of whatever vagal fibers remained in the gastric wall. Short-term results demonstrate that successful PGV can be performed w ith minimally invasive methods.