EFFECT OF INTRATESTICULAR ADMINISTRATION OF ANTI-CORTICOTROPIN-RELEASING FACTOR ANTISERUM (A-CRF) ON TESTICULAR FUNCTION IN NEONATAL RATS

Citation
I. Gerendai et al., EFFECT OF INTRATESTICULAR ADMINISTRATION OF ANTI-CORTICOTROPIN-RELEASING FACTOR ANTISERUM (A-CRF) ON TESTICULAR FUNCTION IN NEONATAL RATS, Andrologia, 25(4), 1993, pp. 211-215
Citations number
28
Categorie Soggetti
Andrology
Journal title
ISSN journal
03034569
Volume
25
Issue
4
Year of publication
1993
Pages
211 - 215
Database
ISI
SICI code
0303-4569(1993)25:4<211:EOIAOA>2.0.ZU;2-7
Abstract
The possible physiological role of testicular corticotropin-releasing factor (CRF) in the regulation of testicular functions was studied in neonatal rats. Two microlitres of anti-CRF-antiserum (dilution: 1 : 10 or 1 : 100) was injected intratesticularly to 5 d-old rats with two t estes and to hemicastrates. Five days after hemicastration and treatme nt of the remaining testis with the antiserum, serum testosterone conc entration and basal testosterone secretion in vitro decreased signific antly. Unilateral testicular injection of a-CRF in rats with two teste s resulted in a significant drop in serum testosterone level with no c hange in basal testosterone production. Data indicate that in neonatal rats testicular CRF might be a local stimulator of steroidogenesis.