N. Mehra et Vk. Bhasin, IN-VITRO GAMETOCYTOCIDAL ACTIVITY OF ARTEMISININ AND ITS DERIVATIVES ON PLASMODIUM-FALCIPARUM, Japanese Journal of Medical Science & Biology, 46(1), 1993, pp. 37-43
Artemisinin and six of its derivatives were evaluated for their in vit
ro gametocytocidal and erythrocytic schizontocidal properties on an In
dian isolate of Plasmodium falciparum. One of the metabolic derivative
s, DADF-dihydroartemisinin (NIH02), was found to possess gametocytocid
al and erythrocytic schizontocidal properties similar to those of arte
misinin. Gametocytes of this isolate were highly susceptible to the to
xic effect of NIH02 (IC50=6.6 ng/ml) and younger stages were more sens
itive. This is the first report about the in vitro game to cytocidal p
roperties of a derivative of artemisinin.