What makes some firms more effective than others in new product develo
pment? Answers are proposed based on evidence from five Canadian medic
al biotechnology firms that varied in effectiveness. A framework of st
rategic change1 was used to describe the firms. As regards their inter
nal context, the more effective firms had inventor-entrepreneurs, more
continuous leadership and more complete management teams. The externa
l context of the effective firms was broader (e.g., incorporating univ
ersities), and they had more focused strategies and targeted larger ma
rkets. The strategy process of the effective and less effective firms
differed as well. These differences between the less effective and mor
e effective firms, seemed to stem from different managerial logics of
action. These findings have implications for managers involved in new
product development.