CHARACTERIZATION OF ISOMERS WHICH ARE PRODUCED BY REACTIONS OF (1R,3S-CYCLOHEXANEDIAMINE)PLATINUM(II) WITH NUCLEOTIDE D(GPG)

Authors
INAGAKI K SAWAKI K
Citation
K. Inagaki et K. Sawaki, CHARACTERIZATION OF ISOMERS WHICH ARE PRODUCED BY REACTIONS OF (1R,3S-CYCLOHEXANEDIAMINE)PLATINUM(II) WITH NUCLEOTIDE D(GPG), Bulletin of the Chemical Society of Japan, 66(6), 1993, pp. 1822-1825
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
66
Issue
6
Year of publication
1993
Pages
1822 - 1825
Database
ISI
SICI code
0009-2673(1993)66:6<1822:COIWAP>2.0.ZU;2-2
Abstract
Two adducts obtained from reactions of dinucleotide (d(GpG)) with 1R,3 S-cyclohexanediamineplatinum-(II) have been investigated on the basis of NMR spectroscopy. They were assigned as interbase cross-linked addu cts being platinated at the N7 positions of the adjacent guanine bases . Both isomers differ with respect to the orientation of the cyclohexa ne ring toward the carbonyl group at the 6 position of the adjacent gu anine bases. A conformational analysis of the cyclohexane ring is also described.