A NEW SYNTHETIC ROUTE TO THE PREVIOUSLY UNATTAINABLE 3-SUBSTITUTED 2,3-DIHYDRO-1,4-DIOXINO[2,3-B]PYRIDINES

Authors
BENARAB A POIROT P GUILLAUMET G
Citation
A. Benarab et al., A NEW SYNTHETIC ROUTE TO THE PREVIOUSLY UNATTAINABLE 3-SUBSTITUTED 2,3-DIHYDRO-1,4-DIOXINO[2,3-B]PYRIDINES, Heterocycles, 36(7), 1993, pp. 1589-1599
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
36
Issue
7
Year of publication
1993
Pages
1589 - 1599
Database
ISI
SICI code
0385-5414(1993)36:7<1589:ANSRTT>2.0.ZU;2-G
Abstract
A variety of ubstituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines (3) ha ve been synthesized from the readily available 2-chloro-3-oxiranylmeth oxypyridine (1). Treatment of this epoxide by various nucleophile reag ents provided alcohols (2a-i) which, by displacement of the chlorine, gave the desired products (3a-i) in satisfactory yields.