A ONE-STEP SYNTHESIS OF 2,3-DIHYDRO-1,4-BENZOTHIAZINES AND PHENOTHIAZINES FROM 1,3-THIAZOLIDINE DERIVATIVES OF CYCLOHEXANONES

Authors
CAPUTO R FERRERI C LONGOBARDO L MASTROIANNI D PALUMBO G PEDATELLA S
Citation
R. Caputo et al., A ONE-STEP SYNTHESIS OF 2,3-DIHYDRO-1,4-BENZOTHIAZINES AND PHENOTHIAZINES FROM 1,3-THIAZOLIDINE DERIVATIVES OF CYCLOHEXANONES, Heterocycles, 36(7), 1993, pp. 1641-1644
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
36
Issue
7
Year of publication
1993
Pages
1641 - 1644
Database
ISI
SICI code
0385-5414(1993)36:7<1641:AOSO2A>2.0.ZU;2-E
Abstract
N-Acetyl-1,3-thiazolidine derivatives of cyclohexanones, when treated with a threefold excess N-bromosuccinimide in anhydrous chloroform at room temperature, smoothly afford N-acetyl-2,3-dihydro-1,4-benzothiazi nes. This represents the first general route to such heterocyclic syst em in one step from aliphatic precursors. The synthesis of optically a ctive N-acetyl-2,3-dihydro-1,4-benzothiazines is also reported.