DNA-PLOIDY OF BASAL-CELL CARCINOMA DETERMINED BY IMAGE CYTOMETRY OF FRESH SMEARS

Authors
HERZBERG AJ GARCIA JA KERNS BJ JORDAN PA PENCE JC ROTTER SM DZUBOW LM
Citation
Aj. Herzberg et al., DNA-PLOIDY OF BASAL-CELL CARCINOMA DETERMINED BY IMAGE CYTOMETRY OF FRESH SMEARS, Journal of cutaneous pathology, 20(3), 1993, pp. 216-222
Citations number
13
Categorie Soggetti
Pathology,"Dermatology & Venereal Diseases
Journal title
Journal of cutaneous pathology → ACNP
ISSN journal
03036987
Volume
20
Issue
3
Year of publication
1993
Pages
216 - 222
Database
ISI
SICI code
0303-6987(1993)20:3<216:DOBCDB>2.0.ZU;2-4
Abstract
Image analysis of nuclear DNA content (DNA ploidy) was performed on sm ears of basal cell carcinoma (BCC) obtained during Mohs microscopicall y-controlled surgery from 51 tumors. DNA ploidy was compared with hist ologic growth pattern and the contour of the invading edge. There was a statistically significantly increased frequency of DNA aneuploidy in smears from BCC exhibiting partial or total diffuse (infiltrative and superficial multicentric) growth patterns (80%; 32 of 40) as compared to solely circumscribed growth patterns (0%; 0 of 11) (p < 0.001).