THE INFLUENCE OF AGE ON THE DEVELOPMENT OF 2-KIDNEY, ONE-CLIP HYPERTENSION IN THE RAT

Authors
KUNES J
Citation
J. Kunes, THE INFLUENCE OF AGE ON THE DEVELOPMENT OF 2-KIDNEY, ONE-CLIP HYPERTENSION IN THE RAT, Physiological Research, 42(3), 1993, pp. 205-208
Citations number
16
Categorie Soggetti
Physiology
Journal title
Physiological Research → ACNP
ISSN journal
08628408
Volume
42
Issue
3
Year of publication
1993
Pages
205 - 208
Database
ISI
SICI code
0862-8408(1993)42:3<205:TIOAOT>2.0.ZU;2-8
Abstract
The role of age in the development of two-kidney, one-clip (2K1C) rena l hypertension was evaluated. Blood pressure response to aortic constr iction was more pronounced in young rats although the alterations of r enal renin activity and body fluid volumes were greater in adult ones. Obtained results suggested that 2K1C renal hypertenslon is maintained by reciprocal interaction of renin-angiotensln system and body fluid volume alterations only in adult rats. In young rats other factors mig ht be more important.