Morphine (0.1 mg/kg) diluted with 0.9% saline to a volume of 0.13 mL/k
g was administered into the epidural space at the lumbosacral junction
in 10 halothane-anesthetized goats immediately before discontinuation
of halothane. The same volume of 0.9% saline was given to control gro
up of eight anesthetized goats. Both groups had undergone an orthopedi
c procedure that replaced the anterior cruciate ligament with a patell
ar tendon autograft. The appearance and unprovoked behavior of goats i
n the morphine group were significantly different (p < .05) from the s
aline groups. The goats in the morphine group were more sedate and str
uggled less during recovery. Epidural morphine did not produce respira
tory depression or bloat during a 9 hour observation period. Heart rat
e, respiratory rate, and blood pressure (mean, systolic, and diastolic
) of the morphine group did not differ from those of the control group
.