PRENATAL COCAINE EXPOSURE - DECREASED SENSITIZATION TO COCAINE AND DECREASED STRIATAL DOPAMINE TRANSPORTER BINDING IN OFFSPRING

Authors
BYRNES JJ PRITCHARD GA KOFF JM MILLER LG
Citation
Jj. Byrnes et al., PRENATAL COCAINE EXPOSURE - DECREASED SENSITIZATION TO COCAINE AND DECREASED STRIATAL DOPAMINE TRANSPORTER BINDING IN OFFSPRING, Neuropharmacology, 32(7), 1993, pp. 721-723
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
32
Issue
7
Year of publication
1993
Pages
721 - 723
Database
ISI
SICI code
0028-3908(1993)32:7<721:PCE-DS>2.0.ZU;2-P
Abstract
Pregnant mice were treated with cocaine, 10 mg/kg/day, during days 13 to 20 of gestation. Cocaine sensitization and dopamine transporter bin ding were evaluated in offspring at 6 weeks of age. Sensitization, def ined as the increase in activity after 5 injections of cocaine compare d to 1 injection, was reduced in cocaine-exposed mice. Dopamine transp orter binding in striatum was also significantly reduced in cocaine-ex posed mice compared to controls.