RELATIONSHIP BETWEEN LUNG-TISSUE AND BLOOD-PLASMA CONCENTRATIONS OF INHALED BUDESONIDE

Authors
VANDENBOSCH JMM WESTERMANN CJJ AUMANN J EDSBACKER S TONNESSON M SELROOS O
Citation
Jmm. Vandenbosch et al., RELATIONSHIP BETWEEN LUNG-TISSUE AND BLOOD-PLASMA CONCENTRATIONS OF INHALED BUDESONIDE, Biopharmaceutics & drug disposition, 14(5), 1993, pp. 455-459
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biopharmaceutics & drug disposition → ACNP
ISSN journal
01422782
Volume
14
Issue
5
Year of publication
1993
Pages
455 - 459
Database
ISI
SICI code
0142-2782(1993)14:5<455:RBLABC>2.0.ZU;2-W
Abstract
In 11 patients, in whom a lung lobe or whole lung was to be resected, a single dose of 1.6 mg inhaled budesonide was given pre-operatively. In 9 of them, concentrations of the drug in both lung tissue and blood plasma were measured. Budesonide concentrations in lung tissue, at le ast 90 min after dosage, were 2.1-8.9 nmol kg-1. Concentrations in blo od plasma (0.27-1.1 nmol kg-1) were 1/8th of those in lung tissue.