Jmm. Vandenbosch et al., RELATIONSHIP BETWEEN LUNG-TISSUE AND BLOOD-PLASMA CONCENTRATIONS OF INHALED BUDESONIDE, Biopharmaceutics & drug disposition, 14(5), 1993, pp. 455-459
In 11 patients, in whom a lung lobe or whole lung was to be resected,
a single dose of 1.6 mg inhaled budesonide was given pre-operatively.
In 9 of them, concentrations of the drug in both lung tissue and blood
plasma were measured. Budesonide concentrations in lung tissue, at le
ast 90 min after dosage, were 2.1-8.9 nmol kg-1. Concentrations in blo
od plasma (0.27-1.1 nmol kg-1) were 1/8th of those in lung tissue.