S. Blandamura et al., COMBINED GRANULAR-CELL TUMOR OF THE ESOPHAGUS AND STOMACH - A CASE-REPORT AND REVIEW OF THE LITERATURE, The Italian Journal of Gastroenterology, 25(5), 1993, pp. 259-264
The case of a 56-year-old man with contemporary benign granular cell t
umour of the oesophagus and stomach is reported. Surgical resection of
the oesophagus and stomach was performed after the diagnosis of squam
ous cell carcinoma on a superficial oesophageal biopsy which showed a
pseudo-epitheliomatous hyperplasia of the stratified squamous epitheli
um covering the oesophageal Granular Cell Tumour (GCT). Hyperplasia wa
s also found in the overlying gastric mucosa. Eight GCTs of the oesoph
agus, observed between 1980 and 1985, were reevaluated to compare the
neoplastic characteristics and the occurrence of overlying epithelial
hyperplasia. Only one patient was female; three had multiple oesophage
al tumours and four showed pseudo-epitheliomatous hyperplasia. A revie
w of the literature is included with emphasis on the rare cases of mul
tiple GCTs. The association of chronic alcoholism with GCT of the gast
ro-intestinal tract is also stressed.