A COMPARISON BETWEEN NEBULIZED TERBUTALINE, NEBULIZED CORTICOSTEROID AND SYSTEMIC CORTICOSTEROID FOR ACUTE WHEEZING IN CHILDREN UP TO 18 MONTHS OF AGE

One hundred and twenty-three children, aged 1.5-18 months, participate d in a randomized, double-blind, placebo-controlled multicentre study comparing different treatments for acute wheezing. The children were a dmitted to one of five participating paediatric departments. They were randomized into one of four treatment groups. (1) soluble prednisolon e + placebo inhalation + terbutaline inhalation; (2) soluble placebo budesonide inhalation + terbutaline inhalation; (3) soluble placebo placebo inhalation + terbutaline inhalation; and (4) soluble placebo + placebo inhalation + normal saline inhalation. On admission, measure ments of temperatures, respiratory rate and heart rate were made and o nce-a-day thereafter. Wheezing, accessory respiratory muscle use, prol onged expiration and general condition were scored on a scale ranging from 0 to 3. Significantly more treatment failures were recorded in th e placebo group. Children from both steroid groups were discharged ear lier than children from the terbutaline group. Compared with children from the placebo group, children from all three treatment groups had a greater improvement in symptom score, but this was significant for th e budesonide group only.