T. Ohzeki et al., IMMUNODEFICIENCY WITH INCREASED IMMUNOGLOBULIN-M ASSOCIATED WITH GROWTH-HORMONE INSUFFICIENCY, Acta paediatrica, 82(6-7), 1993, pp. 620-623
Growth hormone deficiency associated with hypogammaglobulinemia has be
en reported only in a few publications. Our patient was a male with re
current episodes of infections. Serum immunoglobulin (Ig) G was extrem
ely low although IgM concentration was much greater than the normal li
mit. Growth hormone responses to insulin, 1-Dopa and growth hormone-re
leasing hormone were low. The mean growth hormone concentration during
sleep was less than the normal limit. These results are consistent wi
th hyper-IgM immunodeficiency associated with growth hormone deficienc
y. The mode of transmission appears to be autosomal dominant. This com
bination has not been reported previously.