IMMUNODEFICIENCY WITH INCREASED IMMUNOGLOBULIN-M ASSOCIATED WITH GROWTH-HORMONE INSUFFICIENCY

Growth hormone deficiency associated with hypogammaglobulinemia has be en reported only in a few publications. Our patient was a male with re current episodes of infections. Serum immunoglobulin (Ig) G was extrem ely low although IgM concentration was much greater than the normal li mit. Growth hormone responses to insulin, 1-Dopa and growth hormone-re leasing hormone were low. The mean growth hormone concentration during sleep was less than the normal limit. These results are consistent wi th hyper-IgM immunodeficiency associated with growth hormone deficienc y. The mode of transmission appears to be autosomal dominant. This com bination has not been reported previously.