IMPACT OF THE STRUCTURE OF PHOSPHOLIPID DISPERSIONS ON THE STABILITY OF FLUOROCARBON PHOSPHOLIPID EMULSIONS FOR BIOMEDICAL USES

Citation
C. Cornelus et al., IMPACT OF THE STRUCTURE OF PHOSPHOLIPID DISPERSIONS ON THE STABILITY OF FLUOROCARBON PHOSPHOLIPID EMULSIONS FOR BIOMEDICAL USES, Colloids and surfaces. A, Physicochemical and engineering aspects, 70(3), 1993, pp. 233-238
Citations number
14
Categorie Soggetti
Chemistry Physical
ISSN journal
09277757
Volume
70
Issue
3
Year of publication
1993
Pages
233 - 238
Database
ISI
SICI code
0927-7757(1993)70:3<233:IOTSOP>2.0.ZU;2-N
Abstract
The preparation of injectable fluorocarbon emulsions includes the disp ersion of the phospholipids in the aqueous phase, then the admixing of the fluorocarbon to produce a crude premix; emulsification is then ac hieved using a high pressure mechanical procedure, followed by final h eat-sterilization. In this work we report that, depending on the proce dure used and energy applied, the dispersions of phospholipids consist of poorly organized unclosed ''pre-liposomes'', multilamellar vesicle s (MLV), or small unilamellar vesicles (SUV). This has a significant i mpact on the stability of the final fluorocarbon emulsions (90% (w/v) concentration), those prepared from ''pre-liposomes'' being more stabl e than those prepared from MLV or SUV. The first emulsion is shown to contain less fluorocarbon-free phospholipid vesicles than the other tw o. These free vesicles have previously been reported to have a detrime ntal effect on the stability of concentrated fluorocarbon emulsions.