MALIGNANT EPITHELIAL TUMORS IN CHILDREN - INCIDENCE AND ETIOLOGY

Citation
M. Alsheyyab et al., MALIGNANT EPITHELIAL TUMORS IN CHILDREN - INCIDENCE AND ETIOLOGY, Medical and pediatric oncology, 21(6), 1993, pp. 421-428
Citations number
23
Categorie Soggetti
Oncology,Pediatrics
ISSN journal
00981532
Volume
21
Issue
6
Year of publication
1993
Pages
421 - 428
Database
ISI
SICI code
0098-1532(1993)21:6<421:METIC->2.0.ZU;2-9
Abstract
The purpose of this study was to establish the incidence of carcinomas in children, changes in incidence over a 30-year period, and to ident ify features of possible aetiological significance. A total of 173 cas es were identified, but after review of the histopathology, 30 patient s were excluded because they were considered to have benign epithelial tumours or malignant tumours of nonepithelial origin. Seven other cas es were excluded because pathology material was not available. Overall , in 28% of cases, the diagnoses were changed by pathology review. Thu s, 136 children in the West Midlands Region diagnosed 1957-1986 were i ncluded, with carcinoid tumours (44) and tumours of skin (22), nasopha rynx (14), salivary gland (13), adrenal cortex (13), thyroid (9), larg e bowel (5), other (16). Excluding carcinoids, the age-standardised in cidence rate was 2.4 x 10(6) per year. Male:female ratio was 0.7:1 and 66% were aged >10 years. Incidence increased from 1.5 to 3.3 x 10(6) per year. Genetic factors predisposing to carcinoma included tyrosinos is, MEN II and III, congenital adrenal hyperplasia and basal cell naev us syndrome. There was a case of Li-Fraumeni syndrome and several othe r patients had relevant family histories. Probable ''environmental'' c auses included antenatal exposure to stilboestrol or hydroxyprogestero ne hexanoate, stilboestrol given for premature menarche, neonatal hepa titis and prior radiotherapy. The aetiology of carcinomas in children is multifactorial, both genetic and environmental factors being import ant. The incidence is increasing. (C) 1993 Wiley-Liss, Inc.