STRUCTURAL AND FUNCTIONAL-CHARACTERISTICS OF RED-BLOOD-CELLS IN LYMPHOMAS

Significant changes have been recorded in the concentration of sulfhyd ryl groups, histidine, lipoproteins, catalase activity, saponin resist ance, and kinetics of chemiluminescent responses of red blood cells in lymphoma patients. Lymphosarcoma is characterized by changes in the s tructure and function of red blood cells at the early stage of the pro cess, whereas in lymphogranulomatosis changes are observed with the di sease progressing, when pronounced signs of tumor intoxication are not ed and anemia is present. In lymphosarcoma patients an increase of per ipheral blood mononuclears is recorded which expresses the erythroid d ifferentiating antigens with the use of monoclonal antibodies against glycoforin A (ZAE-3) and human erythroblast antigen AG-EB (HAE-9). In lymphogranulomatosis patients it was not detected.