ASSAY OF ADENINE-NUCLEOTIDE LEVEL IN PLATELET STORAGE POOL FOR EVALUATION OF HEMOBLASTOSIS COURSE

The content of adenine nucleotides (ATP, ADP) was studied in dense gra nules of platelets in hemoblastosis to estimate the character of the p athological process course. Varying biochemical defects were observed at the levels of ATP and ADP depending on the severity of the patholog ical process in chronic myeloid leukemia, acute lymphoblastic leukemia , acute myeloblastic and acute myelo-monoblastic leukemias. Adenine nu cleotide values can be used for the diagnosis of varying stages of the above diseases, for the evaluation of anomalous platelets, and charac terization of the adequacy of the bone marrow hemopoiesis.