A. Schieppati et al., PROGNOSIS OF UNTREATED PATIENTS WITH IDIOPATHIC MEMBRANOUS NEPHROPATHY, The New England journal of medicine, 329(2), 1993, pp. 85-89
Background. Defining the most appropriate treatment for patients with
idiopathic membranous nephropathy is a matter of controversy. The cour
se of the disorder is often benign, and the immunosuppressive regimens
used in some patients have uncertain benefits and substantial risks.
We studied the natural history of idiopathic membranous nephropathy in
patients who received only symptomatic therapy. Methods. We prospecti
vely studied 100 consecutive patients (68 men and 32 women; mean [+/-S
D] age, 51+/-17 years) with biopsy-proved idiopathic membranous nephro
pathy. The patients received diuretic or antihypertensive drugs as nee
ded, but no glucocorticoid or immunosuppressive drugs. We examined the
patients and measured their urinary protein excretion and serum creat
inine concentrations every 6 months for a mean of 52 months. Results.
Twenty-four (65 percent) of the 37 patients followed for at least five
years had complete or partial remission of proteinuria; in 6 others (
16 percent), end-stage renal disease developed, and they required dial
ysis. As calculated by the Kaplan-Meier method, the estimated probabil
ity (+/- the standard error of the estimate) of retaining adequate kid
ney function was 88+/-5 percent after five years and 73+/-7 percent af
ter eight years. The prognosis was poorer in men and in patients over
50 years of age, but not in patients with the nephrotic syndrome, hype
rtension, or hypercholesterolemia. Conclusions. Most untreated patient
s with idiopathic membranous nephropathy maintain renal function for p
rolonged periods and are likely to have spontaneous remission. These r
esults do not support the use of glucocorticoids and immunosuppressive
drugs in patients with idiopathic membranous nephropathy.