S. Vivrette et al., HEMODIALYSIS FOR TREATMENT OF OXYTETRACYCLINE-INDUCED ACUTE-RENAL-FAILURE IN A NEONATAL FOAL, Journal of the American Veterinary Medical Association, 203(1), 1993, pp. 105-107
Acute renal failure in a 4-day-old foal secondary to oxytetracycline t
oxicosis was treated by hemodialysis. Oxytetracycline had been adminis
tered as treatment for forelimb flexor tendon contracture. Conservativ
e treatment with fluids, furosemide, and dopamine partially alleviated
serum electrolyte concentration imbalances, but was ineffective in pr
omoting diuresis or decreasing azotemia, Three hemodialysis treatments
over 4 days were administered, after which the clinical appearance of
the foal improved, and biochemical and electrolyte values returned to
within reference ranges. The nephrotoxic potential of oxytetracycline
should be considered prior to its administration. Hemodialysis may be
a treatment option in management of acute renal failure in foals that
are nonresponsive to conservative medical treatment.