Sp. Gupta et V. Mulchandani, QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON BENZODIAZEPINE RECEPTOR-BINDING - INVESTIGATION OF INTERACTION-MODEL, Indian Journal of Biochemistry & Biophysics, 30(3), 1993, pp. 181-186
With a view to providing perfection to the benzodiazepine receptor mod
el proposed earlier [S P Gupta, R N Saha & V Mulchandani (1992) J. Mol
Recog 5, 75-80] a few more QSAR studies on a series of 9-benzylpurine
s and tetracyclic 1,4-benzodiazepine derivatives have been made. The m
odels showing the interaction of these compounds with the receptor are
proposed. It is found that the receptor model, unlike the one propose
d earlier, requires the presence of a polar site along with all the ot
her essential sites.