SERIAL STUDY OF NEUROPSYCHOLOGICAL PERFORMANCE AND GADOLINIUM-ENHANCED MRI IN MS

Many multiple sclerosis patients show cognitive decline, although no d efinite correlation between brain demyelination at MRI and neuropsycho logical performance has been found so far. We submitted a group of nin e relapsing-remitting, mildly disabled patients to both serial gadolin ium-DTPA enhanced MRI and neuropsychological evaluation in a follow up period of three months. Despite the great variability in acute lesion s' load, no overall decline in test, performance was found. Furthermor e, in selected cases whose test scores declined at follow up, no conco rdance with the new lesion load was found.