We present a case of Sneddon's syndrome with high titers of antiphosph
olipid antibodies (APLA), in which the leading symptom was an incapaci
tating memory defect. MRI revealed vasculitic lesions of the central n
ervous system (CNS). Therefore immunosuppressive therapy was started w
ith steroids and cyclophosphamide pulses. The transient beneficial eff
ects of such a therapy will be discussed.