A 63-year-old woman presented with mild arthralgias and inability to s
tand and walk without other significant neuropsychiatric abnormality.
Neurological explorations showed intrathecal oligoclonal immunoglobuli
n production in CSF and numerous bright foci at brain MRI. A primary S
jogren's syndrome was concomitantly evidenced and was thought to be th
e cause of the astasia-abasia symptom by multiple brain involvement. P
atient's condition gradually improved with hydroxychloroquine and cort
icosteroid therapy. Central nervous system involvement by primary Sjog
ren's syndrome is discussed.