The catastrophic reaction is a rare affective disorder following left
hemispheric strokes. It is characterized by a disruptive emotional out
burst involving anxiety, agitation and aggressive behavior. A case is
presented that appears to underscore the intense frustration that thes
e individuals experience when they cannot adequately express themselve
s through language. The catastrophic reaction behavior proved to be un
remitting and failed to respond to withdrawal of the patient from thre
atening or difficult therapies, use of medications or attempts at beha
vioral modification. The catastrophic reaction appears to be a specifi
c consequence of the intense frustration and perceived loss associated
with an expressive aphasia. This may help explain the reportedly high
er incidence of depression in left frontal strokes.