PERSISTENCE OF HUMAN PAPILLOMAVIRUS TYPE-6E IN ADULT MULTIPLE LARYNGEAL PAPILLOMA AND THE COUNTERPART FALSE CORD OF AN INTERFERON-TREATED PATIENT

Human papillomavirus (HPV) type 6e DNA was detected in a laryngeal pap illoma, in a papilloma recurring after an interval of six years and in the counterpart clinically-normal false cord of the same patient. No detectable subgroup change of HPV DNA occurred during the clinical cou rse, which included therapy by CO2 laser followed by intramuscular alp ha-interferon injection. The data demonstrated a single subtype of HPV to have persisted, and the prevention of a recurrence of laryngeal pa pilloma during our patient's long clinical course to have failed, in s pite of the interferon treatment.