LAMININ MATRIX FORMATION AND S-100 PROTEIN AND OR DESMIN-POSITIVE CELLS IN MALIGNANT FIBROUS HISTIOCYTOMA (MFH)

16/30 human storiform-pleomorphic malignant fibrous histiocytomas (MFH ) showed a focal pericellular immunostaining for laminin. 14/16 of the se laminin-positive tumours additionally revealed an atypical cellular differentiation (desmin- and/or S-100 protein-positive cells). The si gnificance of focal laminin positivity along with atypical, non-entity specific differentiated cells is discussed before the background of l aminin as being an indicator and promoter of differentiation in MFH. T he limited value of a laminin detection in MFH for solving differentia l diagnostic questions (MFH versus other poorly differentiated sarcoma s with basement membrane formation) has been pointed out.