EVALUATION OF VOLUME-WEIGHTED MEAN NUCLEAR VOLUME IN ENDOMETRIAL LESIONS

The individual nuclear size was studied in three groups of endometrial samples (simple hyperplasia -SH-, atypical hyperplasia -AH-, and well -differentiated adenocarcinoma -WDA-). The application of recent semiq uantitative systems in combination with stereological methods permits a simple, quick and unbiased estimation of the volume-weighted mean nu clear volume v(v)(nucl)BAR. We have found an increase in the v(v)(nucl )BAR from SH to AH to WDA. There are significant differences between t he mean of the three groups (p<0.01). The variance associated with est imates of v(v)(nucl)BAR is mainly provided by differences among lesion s; i.e. patients. This capacity for discriminating may be associated w ith gland and lumen endometrial quantification to improve the correct diagnosis of endometrial samples.