ORTHOSTATIC HYPOTENSION - WITH PARTICULAR REFERENCE TO EXPERIMENTALLY-INDUCED ORTHOSTATIC HYPOTENSION IN DOGS

Blood pressure (BP) and heart rate (HR) were measured while standing i n a stable position for SPF beagle dogs consisting of 4 females with a n average weight of 8.73+/-0.58 kg and average age of 7.38+/-0.12 mont hs. No anesthetic was used during the procedure. These dogs were subje cted to a postural change, a 90-degrees-tilt standing position, and BP and HR were measured one minute and ten minutes later. In addition, 2 0 mg/kg of tetraethyl-ammonium bromide (TEA) as a gangliolytic drug wa s administered by i.v. injection within 30 seconds, and then BP and HR were measured in the resting state for 20 minutes. When changing from the resting position to the 90-degrees-tilt standing position after a dministration of TEA, these were significant decreases in systolic BP, diastolic BP and mean arterial BP one minute and ten minutes later. A n experimental model of orthostatic hypotension was considered to have been achieved during these methods.