Raynaud's syndrome is a clinical entity characterized by episodic vasc
ular spasm and digital ischemia occurring in response to cold or emoti
onal stimuli. Most patients with Raynaud's syndrome are successfully m
anaged with medical therapy. Surgical sympathectomy is rarely performe
d and its use remains controversial. Of 3,219 patients seen with the d
iagnosis of Raynaud's disease, phenomenon or syndrome over the last 10
years at Mayo Clinic, 20 cervical or thoracic sympathectomies were pe
rformed in 14 (0.4%) patients. Of all patients who underwent cervico t
horacic sympathectomy (68) for various reasons during the same time pe
riod, 20,5% (14/68) were performed for Raynaud's syndrome. Surgical sy
mpathectomy was reserved for those rare patients with persistent, seve
re symptoms (pain, ulcer) despite intensive medical treatment. Surgica
l therapy was also used for those few patients with occupations involv
ing exposure to cold and disabling, refractory symptoms in hopes of al
lowing them to return to work. Transaxillary (12 limbs) or supraclavic
ular (8 limbs) exposure and resection of the sympathetic chain with T1
-T4 ganglions was usually performed. Initial resolution or improvement
of symptoms was achieved in 19/20 (95%) of limbs. Both patients with
digital ulceration healed. Although improved in some, persistent or re
current symptoms were present in all patients after six months postope
ratively. Increased sensitivity of digital vessels to circulating cate
cholamines, nerve fiber regeneration or incomplete sympathectomy have
been postulated to lead to recurrence. Five patients developed Horner'
s syndrome postoperatively. A portion of the stellate ganglion was int
entionally resected in 3 of the 5 patients. While cervicothoracic symp
athectomy can be safely performed in patients with Raynaud's syndrome
who do not respond to medical therapy and initial symptomatic relief c
an be expected in most patients, the natural course of the disease app
ears to be unaffected and significant long-term benefit remains unprov
en.