INTRAOCULAR DEXAMETHASONE PENETRATION VIA SUBCONJUNCTIVAL OR RETROBULBAR INJECTIONS IN RABBITS

Citation
Fs. Bodker et al., INTRAOCULAR DEXAMETHASONE PENETRATION VIA SUBCONJUNCTIVAL OR RETROBULBAR INJECTIONS IN RABBITS, Ophthalmic surgery, 24(7), 1993, pp. 453-457
Citations number
17
Categorie Soggetti
Ophthalmology,Surgery
Journal title
ISSN journal
0022023X
Volume
24
Issue
7
Year of publication
1993
Pages
453 - 457
Database
ISI
SICI code
0022-023X(1993)24:7<453:IDPVSO>2.0.ZU;2-N
Abstract
Using high-performance liquid chromatography, we compared tissue level s of dexamethasone in the aqueous, vitreous, retina, and choroid of ra bbits, 1 and 4 hours following subconjunctival or retrobulbar injectio n. One hour following injection, dexamethasone levels in all of these tissues were similar in both the subconjunctival and retrobulbar group s. Four hours following injection, the concentrations in the two group s also were similar, except in the choroid, in which the subconjunctiv al injection yielded significantly lower dexamethasone levels than the retrobulbar injection. Tissue steroid levels were comparable ipsilate ral and contralateral to the injected eyes in both treatment groups af ter 4 hours, except in the retina, in which the levels were lower in t he contralateral eye after subconjunctival injection. These data sugge st that dexamethasone absorption and delivery is predominantly hematog enous following both subconjunctival and retrobulbar injection, especi ally in highly vascular tissues, such as the choroid. Hematogenous del ivery of dexamethasone appears to peak earlier in the choroid and pres umably in other intraocular tissues following subconjunctival injectio ns, while retrobulbar injections provide more steady, long-term delive ry.