SYNERGISTIC EFFECT OF ORAL UFT IN COMBINATION WITH CISPLATIN ON DNA-SYNTHESIS IN RAT HEPATOCARCINOMAS

Authors
SAKAMOTO S TAGA H UCHIKOSHI T KUDO H SUZUKI S SUGIURA Y KUWA K ENDO Y
Citation
S. Sakamoto et al., SYNERGISTIC EFFECT OF ORAL UFT IN COMBINATION WITH CISPLATIN ON DNA-SYNTHESIS IN RAT HEPATOCARCINOMAS, Anticancer research, 13(3), 1993, pp. 631-634
Citations number
15
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
13
Issue
3
Year of publication
1993
Pages
631 - 634
Database
ISI
SICI code
0250-7005(1993)13:3<631:SEOOUI>2.0.ZU;2-3
Abstract
We investigated the synergistic efficacy of CDDP and UFT, an oral anti cancer derivative of 5-fluorouracil, on DNA synthesis of 3'-MeDAB-indu ced hepatocarcinomas in rats. Chronic treatment with CDDP slightly red uced tissue activities of thymidylate synthetase and thymidine kinase in the hepatocarcinomas, and, moreover, simultaneous administration of a low dose of UFT with CDDP markedly suppressed both enzyme activitie s, i.e., UFT and CDDP showed a potent synergism on DNA synthesis in he patocarcinomas.