IGG INTERFERENCE IN 2ND-GENERATION ENZYME IMMUNOASSAYS FOR ANTI-HEPATITIS-C VIRUS-ANTIBODIES

Authors
BORQUE L MASIDE C RUS A ELENA A DELCURA J GASTANARES MJ
Citation
L. Borque et al., IGG INTERFERENCE IN 2ND-GENERATION ENZYME IMMUNOASSAYS FOR ANTI-HEPATITIS-C VIRUS-ANTIBODIES, Journal of immunoassay, 14(3), 1993, pp. 183-189
Citations number
9
Categorie Soggetti
Immunology
Journal title
Journal of immunoassay → ACNP
ISSN journal
01971522
Volume
14
Issue
3
Year of publication
1993
Pages
183 - 189
Database
ISI
SICI code
0197-1522(1993)14:3<183:III2EI>2.0.ZU;2-R
Abstract
The interference of endogenous IgG in the identification of an 1-HCV a ntibodies was studied in three second-generation enzymeimmunoassays. T he addition of increasing concentrations of this immunoglobulin led to the appearance of false positives. The results obtained confirm the h ypothesis that a non-specific binding of the IgG with the support mate rial used was responsible for this interference.