EFFECT OF PROTEIN DIETARY LEVEL ON REPAIRTISSUE GENESIS IN GROWING RATS

The objective of this study was to verify if the diet protein level af fects the genesis of the repair tissue in rats submitted to a polychlo rovynil (PVC) sponge implantation, as well as to analyse the possible alterations in the synthesis of the mucopolysaccharides acids (glucosa minoglicans) by the histophotometry technique. Forty five Wistar weanl ing male ratas, at 21 days of age, were divided into three experimenta l groups; the groups were fed diets al 6%, 15% and 40% protein level f rom casein source, during at 69 days period. The animals which receive d the low protein diet (6%) presented an inhibition in the evolution a nd maturation of the granulation tissue mainly in the 4th, 7th and 10t h days after the sponge PVC implantation. It was also observed that th ere was less infiltration of the inflammatory cells, less fiberblasts proliferation, reduction of othe collagen fibers synthesis, neovascula rization decreased and an inhibition of the mucopolysaccharide acids s ynthesis.