PROSTAGLANDIN I2 AND THROMBOXANE-A2 CONTENT IN THE BLOOD OF DOGS IN THE TIME-COURSE OF HEMORRHAGIC-SHOCK

The content of prostaglandin I2 (PGI2) and thromboxan (Tx) A2 in the v enous blood was studied in 5 dogs in the time course of hemorrhagic sh ock simulated by a single jet blood-letting from the femoral artery. P GI2 and TxA2 concentrations were estimated by the levels of their stab le metabolites in RIA. It was found that acute hemorrhage stimulated t he synthesis of prostanoids studied up to the animals' death. However, with the shock progressing, a shift took place in the ratio PGI2/TxA2 from 1:3.8 to 1:5.2., due to a higher rise of TxA2. Possible causes o f PGI2 synthesis decrease and TxA2 production increase in hemorrhagic shock were considered. Basing on the data obtained a conclusion has be en made on the necessity of exogenous PGI2 (prostacyclin) inclusion in to the combined therapy of hemorrhagic shock.