CARBOGAL EFFECT ON THE COMPLEMENT-SYSTEM UNDER SIMULATED CONDITIONS AND IN ANIMAL-EXPERIMENTS

Authors
BELTYUKOV PP BOGOMAZ TA GALEBSKAYA LV RYUMINA YV SACHKOV AV SCHERBAK IG
Citation
Pp. Beltyukov et al., CARBOGAL EFFECT ON THE COMPLEMENT-SYSTEM UNDER SIMULATED CONDITIONS AND IN ANIMAL-EXPERIMENTS, Gematologia i transfuziologia, 37(7-8), 1992, pp. 27-28
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
37
Issue
7-8
Year of publication
1992
Pages
27 - 28
Database
ISI
SICI code
0234-5730(1992)37:7-8<27:CEOTCU>2.0.ZU;2-0
Abstract
The influence of dimethylperfluorocyclohexane (carbogal) on the hemoly tic activity of human blood serum complement was studied in vitro. It has been show that different effects of carbogol on the complement dep end on the serum lipid composition. Endotracheal administration of car bogal to rats results in a significant reduction of complement activit y in the animal's blood. Significant changes in the hemolytic activity of the complement recorded 21 days after the endotracheal administrat ion of the compound are, probably, associated with the complement depl etion after its activation by carbogal particles or with disorders in the complement component synthesis by macrophages.