From 1970 to 1991, 295 indigenous cases and one imported case of human
plague were reported in the United States. Eighty-two percent of the
total indigenous cases occurred in New Mexico, Arizona, and Colorado.
Ninety-three percent of these cases had onset in the months of April t
hrough November. Most cases (89%) presented as bubonic or septicemic p
lague, or both. Cases were reported more frequently in males (58%), an
d male mortality exceeded that of females (17 versus 11%). Ground squi
rrels were the most frequently implicated sources of infection in case
s associated with flea bites, and domestic cats were found to play an
increasingly important role in transmission of disease to humans durin
g these decades.