SYNTHESIS OF DRO-5',5',8',8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID FOR BINDING-STUDIES OF RETINOIC ACID RECEPTORS

Authors
DAWSON MI HOBBS PD RHEE SW MORIMOTO H WILLIAMS PG
Citation
Mi. Dawson et al., SYNTHESIS OF DRO-5',5',8',8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID FOR BINDING-STUDIES OF RETINOIC ACID RECEPTORS, Journal of labelled compounds & radiopharmaceuticals, 33(7), 1993, pp. 633-637
Citations number
9
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
7
Year of publication
1993
Pages
633 - 637
Database
ISI
SICI code
0362-4803(1993)33:7<633:SODAF>2.0.ZU;2-R
Abstract
[1',3',4'-H-3(3)]4- (5', 6', 7', 8'-Tetrahydro-5', 5', 8',8'-tetrameth yl-2'-anthracenyl)benzoic acid (specific activity 64 Ci/mmole) was syn thesized by bromination of ethyl o-5',5',8',8'-tetramethyl-2'-anthrace nyl)benzoate, followed by reductive debromination by tritium gas in th e presence of 10% palladium on carbon and hydrolysis. H-1 and H-3 NMR spectroscopy was used to establish tritium at 1',3',4'-tetrahydroanthr acenyl ring positions.