SYNTHESIS OF [H-3] LABELED GLUCOBRASSICIN, A POTENTIAL RADIOTRACER FOR METABOLIC STUDIES OF INDOLE GLUCOSINOLATES

Authors
CHEVOLLEAU S JOSEPH B ROLLIN P TULLIEZ J
Citation
S. Chevolleau et al., SYNTHESIS OF [H-3] LABELED GLUCOBRASSICIN, A POTENTIAL RADIOTRACER FOR METABOLIC STUDIES OF INDOLE GLUCOSINOLATES, Journal of labelled compounds & radiopharmaceuticals, 33(7), 1993, pp. 671-679
Citations number
14
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
7
Year of publication
1993
Pages
671 - 679
Database
ISI
SICI code
0362-4803(1993)33:7<671:SO[LGA>2.0.ZU;2-F
Abstract
Glucobrassicin, an indole glucosinolate widespread in cruciferous plan ts, appears to be involved in anticarcinogenic activity via its breakd own products. In order to study the ''in vivo'' metabolism of glucobra ssicin, we have synthesized the 5-[H-3]-indol-3-ylmethyl glucosinolate (H-3-labelled glucobrassicin) starting from artificial peracetylated 5-bromoindol-3-ylmethyl glucosinolate. The labelled compounds were cha racterized by radio-HPLC and FAB mass spectrometry.