21,24-DINORCHOL-5-EN-22-YNE-3-BETA,17,20-TRIOL - STEREOSELECTIVE SYNTHESIS OF THE 4 DIASTEREOMERS AS INHIBITORS OF ECDYSONE BIOSYNTHESIS

Authors
MAUVAIS A HETRU C LUU B
Citation
A. Mauvais et al., 21,24-DINORCHOL-5-EN-22-YNE-3-BETA,17,20-TRIOL - STEREOSELECTIVE SYNTHESIS OF THE 4 DIASTEREOMERS AS INHIBITORS OF ECDYSONE BIOSYNTHESIS, Tetrahedron letters, 34(27), 1993, pp. 4337-4340
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
27
Year of publication
1993
Pages
4337 - 4340
Database
ISI
SICI code
0040-4039(1993)34:27<4337:2-SS>2.0.ZU;2-R
Abstract
Starting from the two silylated cyanohydrins (2 and 5) we synthesized the four diastereomers of the title compound. This was achieved by add ing either lithium trimethylsilylacetylide or the trimethylsilylacetyl ide magnesium bromide on the corresponding aldhehydes 3 and 6, at -78- degrees-C. These compounds are to be tested as inhibitors of the ecdys one biosynthesis.