DIFFERENT RESPONSE OF BRAIN CHOLECYSTOKININ CONTENT TO INTRAGASTRIC ADMINISTRATION OF TRYPSIN-INHIBITOR (CAMOSTATE) IN YOUNG AND OLD RATS

Authors
MIYASAKA K MATSUMOTO M TOMITA H SAZAKI N OKUBO K SHIKADO F FUNAKOSHI A
Citation
K. Miyasaka et al., DIFFERENT RESPONSE OF BRAIN CHOLECYSTOKININ CONTENT TO INTRAGASTRIC ADMINISTRATION OF TRYPSIN-INHIBITOR (CAMOSTATE) IN YOUNG AND OLD RATS, Archives of gerontology and geriatrics, 16(2), 1993, pp. 165-175
Citations number
31
Categorie Soggetti
Geiatric & Gerontology
Journal title
Archives of gerontology and geriatrics → ACNP
ISSN journal
01674943
Volume
16
Issue
2
Year of publication
1993
Pages
165 - 175
Database
ISI
SICI code
0167-4943(1993)16:2<165:DROBCC>2.0.ZU;2-F
Abstract
The tissue concentrations of cholecystokinin in the intestine and the brain in young (4-8-month-old), and old (26-29-month-old) rats before and after intragastric administration of synthetic trypsin inhibitor ( camostate) were examined. The total cholecystokinin content in the pro ximal intestine was significantly higher in old rats, whereas that in the brain was similar in young and old rats. Intragastric administrati on of camostate significantly increased the plasma cholecystokinin con centration and decreased the intestinal cholecystokinin content in bot h young and old rats. It also decreased the cholecystokinin content in the brain of old rats but not of young rats. These results suggest th at the effect of aging on changes in the tissue content of cholecystok inin varies in different tissues.