Objective. To review the experience of a large children's hospital and
two community hospitals in Chicago in which malaria was diagnosed in
children during a recent 6-year period. Methods. Retrospective medical
record review covering the years 1985 to 1990. Results. Twenty cases
of childhood malaria were diagnosed, generally in patients hospitalize
d for fever unresponsive to oral antibiotics also associated with sple
nomegaly, with presumptive diagnoses of malignancy, typhoid fever, acu
te appendicitis, or urinary tract infection. History of recent immigra
tion to the United States or travel to a malaria-endemic area was freq
uently not elicited until several days into hospitalization, thus dela
ying diagnosis and therapy. Conclusions. Because malaria in the United
States pediatric population has increased as a result of foreign immi
gration and overseas travel, pediatricians must be alert to the possib
ility of malaria in febrile children, and the importance of antimalari
al prophylaxis should be communicated to parents of children traveling
to endemic areas.