SITE SELECTIVITY IN SELF-CATALYZED FUNCTIONALIZATION OF HELICAL POLYPEPTIDE STRUCTURES

Authors
BROO K ALLERT M ANDERSSON L ERLANDSSON P STENHAGEN G WIGSTROM J AHLBERG P BALTZER L
Citation
K. Broo et al., SITE SELECTIVITY IN SELF-CATALYZED FUNCTIONALIZATION OF HELICAL POLYPEPTIDE STRUCTURES, Perkin transactions. 2, (3), 1997, pp. 397-398
Citations number
11
Categorie Soggetti
Chemistry Physical","Chemistry Inorganic & Nuclear
Journal title
Perkin transactions. 2 → ACNP
ISSN journal
03009580
Issue
3
Year of publication
1997
Pages
397 - 398
Database
ISI
SICI code
0300-9580(1997):3<397:SSISFO>2.0.ZU;2-8
Abstract
Histidine side chains in helical structures catalyse-the acylation of flanking lysine, ornithine and 1,3-diaminobutyric acid residues provid ed they are in positions i - 3 and i + 4, but not in positions i - 4, i - 1, i + 2, i + 3, relative to a histidine in position i,in a novel site-selective functionalization reaction that enhances the potential of polypeptide and protein design.