PROGRESS IN THE TOTAL SYNTHESIS OF BREVETOXINS

Authors
REDDY KR SKOKOTAS G NICOLAOU KC
Citation
Kr. Reddy et al., PROGRESS IN THE TOTAL SYNTHESIS OF BREVETOXINS, Gazzetta chimica italiana, 123(6), 1993, pp. 337-341
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Gazzetta chimica italiana → ACNP
ISSN journal
00165603
Volume
123
Issue
6
Year of publication
1993
Pages
337 - 341
Database
ISI
SICI code
0016-5603(1993)123:6<337:PITTSO>2.0.ZU;2-O
Abstract
A number of synthetic methods for the construction of cyclic ethers of the type found in the brevetoxins are described. These methods includ e cyclization reactions involving hydroxy epoxides, hydroxy dithioketa ls and hydroxy ketones, bridging of dithionolactones and dithionoester s, and nucleophilic additions to thionolactones. Application of this t echnology to the total synthesis of hemibrevetoxin B is also discussed .