PROTECTION BY BTCP OF CULTURED DOPAMINERGIC-NEURONS EXPOSED TO NEUROTOXINS

Authors
CERRUTI C DRIAN MJ KAMENKA JM PRIVAT A
Citation
C. Cerruti et al., PROTECTION BY BTCP OF CULTURED DOPAMINERGIC-NEURONS EXPOSED TO NEUROTOXINS, Brain research, 617(1), 1993, pp. 138-142
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
617
Issue
1
Year of publication
1993
Pages
138 - 142
Database
ISI
SICI code
0006-8993(1993)617:1<138:PBBOCD>2.0.ZU;2-Z
Abstract
This study presents 'in vitro' evidence for a protection of cultured d opaminergic neurons against the toxicity of 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpyridinium (MPP+) by pretreatment with BTCP, a s elective and potent dopamine (DA) uptake blocker. Moreover, we show th at, at low concentration (10 nM), treatment with MPP+, which is more s elective than 6-OHDA for dopaminergic neurons, is followed by some reg eneration of these neurons.